Talin carries mechanical force (of 7-10 piconewton) during cell adhesion. It also allows cells to measure extracellular rigidity, since cells in which talin is prevented from forming mechanical linkages can no …

Talin (herein referring to the talin-1 form), is a cytoskeletal adapter protein that binds integrin receptors and F-actin, and is a key factor in the formation and regulation of integrin-dependent cell–matrix …

Talin is a protein that serves as a physical and informational link between a cell’s internal structure and its external environment. Discovered in 1983, it is found in high concentrations where cells attach to …

Talin is a cytoplasmic adapter protein capable of directly connecting integrins to the actin cytoskeleton. Talin consists of an N-terminal head domain (~residues 1–430) responsible for integrin binding, …

Nov 30, 2023 · Although talin is a key factor that translates mechanical forces into chemical responses primarily at sites of cell-matrix and cell-cell junctions, talin may also function in other cellular …

Dec 20, 2023 · Talin is an essential focal adhesion (FA) protein that links F-actin to integrins. F-actin constantly moves on FAs, yet how Talin simultaneously maintains the connection to F-actin and...

Feb 10, 2026 · A collaborative project between the Tanentzapf and Kim labs investigated how the disruption of talin regulation affects platelets and hemostasis 1.

Sep 24, 2021 · Talin is an adapter protein that contains the head domain, which is an atypical FERM domain, and rod domain, consisting of coiled bundles constructed of four or five α-helices. The …

Tallinn is the main governmental, financial, industrial, and cultural centre of Estonia. It is located 187 kilometres (116 mi) northwest of the country's second largest city, Tartu, however, only 80 kilometres …

Talin carries mechanical force (of 7-10 piconewton) during cell adhesion. It also allows cells to measure extracellular rigidity, since cells in which talin is prevented from forming mechanical linkages can no …